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مقاله
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Abstract
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Title:
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Aldose reductase C‑106T gene polymorphism in type 2 diabetics with microangiopathy in Iranian individuals
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Author(s):
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Majid Reza Sheikh Rezaee, Ahmad Ahmadzadeh Amiri, Mohammad Bagher Hashemi‑Soteh1, Fatemeh Daneshvar2, Roghaye Emady‑Jamaly2, Reza Jafari, Behyar Soleimani, Hamed Haghiaminjan3
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Presentation Type:
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Poster
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Subject:
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Molecular Biology and Genetics
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Others:
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Presenting Author:
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Name:
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Ahmad Ahmadzadeh amiri
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Affiliation :(optional)
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Bu Ali‑Sina Clinical Research Development Unit, 1Molecular and Cell Biology Research Center and Medical Faculty, 2Mazandaran University of Medical Sciences, Mazandaran, Sari, 3Departments of Toxicology
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E mail:
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Ahmadzdh@yahoo.com
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Phone:
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2277292
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Mobile:
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09111519257
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Purpose:
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The aim of the following study is to study the association between AR C106T genotypes and diabetic MVCs in Iranian population
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Methods:
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We included 206 type 2 diabetic patients categorized into two groups according to the presence or absence of diabetic microangiopathy. The cases of interest were diabetic neuropathy, retinopathy and nephropathy identifed during clinical and or laboratory examination. In addition, 114 age‑ and sex‑matched individuals were selected to serve as a control group. AR genotyping was done using an amplifcation gel electrophoresis.
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Results:
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The frequency of CC genotype was specifcally higher in subjects with diabetic retinopathy as compared to those without it (53.2% vs. 38.1%, P = 0.030). Patients with diabetic microangiopathy in general; however, did not differ signifcantly between AR genotype groups.
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Conclusion:
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The C-106T polymorphism in the AR gene is likely a risk factor for development of only retinal complication of diabetes microvascular in Iranian individuals.
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Attachment:
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5091poster Aldose.pptx
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