To compare the outcome (efficacy and safety) of the slow cyclophotocoagulation (CPC) to the standard method (pop titration method) in treatment of refractory glaucoma.

36 eyes of 36 patients with refractory glaucoma were enrolled and randomized as group A (slow CPC) with low laser power and doubled exposure time (4 seconds v/s 2 seconds) or group B (standard) with pop titration method of CPC between October 2013 and July 2014 and followed up for 3 months.post treatment IOP, inflammation, number of anti-glaucoma medications, and the degree of post CPC pain compared between groups on 1st, 7th, 30th days after procedure

Both methods are effective in controlling IOP and the success rate between two groups was not significantly different in all follow up visits (p>0.05). Post-treatment anti-glaucoma medications were adjusted according to intraocular pressure and the difference was not significant (p=0.5).Although pain scores and anterior chamber reaction as an inflammation indicator were lower in slow CPC group the difference was not statistically significant on 1st day (p=0.2) and 7th day (p=0.56) post- treatment. No major complication observed.

Slow CPC is effective in controlling refractory glaucoma and post treatment inflammation and pain may be lower than the standard method