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مقاله
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Abstract
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Title:
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Photoreceptor cell derived from bone marrow stromal stem cells in vitro
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Author(s):
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Hamid Aboutaleb kadkhodaeian, Taki Tiraihi, Hamid Ahmadieh, Hosein ziaii Ardakani, Narsis Daftarian
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Presentation Type:
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Oral
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Subject:
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Retina and Retinal Cell Biology
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Others:
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Presenting Author:
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Name:
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Hamid Aboutaleb kadkhodaeean
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Affiliation :(optional)
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Shefa neuroscience research center ,Khatam-Al-Anbia Hospital, Tehran, Iran
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E mail:
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habootaleb92@gmail.com
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Phone:
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09377711768
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Mobile:
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09377711768
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Purpose:
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A hereditary degenerative disease of the retina, retinitis pigmentosa (RP), is the leading cause of visual handicap among working populations in developed countries, with an estimated 1.5 million patients worldwide. Here we used simple method for production of photoreceptor cells in vitro.
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Methods:
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Bone marrow stromal stem cells derived from male pigmented rats. The cells differentiated under the specific medium. After 14 days in vitro the specific markers for sensory retinal cells investigated to determine the differentiation of BMSCs to retinal cells.
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Results:
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Result showed that after 14 days in vitro BMSCs cells differentiated to cells similar to sensory retina in morphology manner. The specific markers for each cell revealed differentiation of BMSCs to retinal cells in vitro.
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Conclusion:
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For the first time in our study, we could differentiate the BMSCs cells to retinal cells such as photoreceptor, amacrine, ganglionic and muller glial cell in a simple method.
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Attachment:
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